Rabbit anti-Human sST2 monoclonal antibody

Size

£372.30

Was £438.00

SKU:: RM17779
Application:: ELISA
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C
Supplier:: Abclonal
Immunogen:: Recombinant Human sST2 Protein
Formulation:: Supplied as a 0.2um filtered solution in PBS with 0.05% Proclin300, PH 7.4.
Species:: Human
Uniprot:: Q01638
Synonyms:: DER4;FIT-1;growth stimulation-expressed;homolog of mouse growth stimulation-expressed;IL33R;interleukin 1 receptor-related protein;interleukin-1 receptor-like 1;Protein ST2;ST2;ST2L;ST2V;T1
Extra Details:: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization