RM17623
Rabbit anti-Human AMH/MIS monoclonal antibody (CAP)
Size
£372.30
Was £438.00
- SKU:
- RM17623
- Additional Names:
- MIF|MIS
- Application:
- ELISA
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Abclonal
- Immunogen:
- Recombinant Human AMH/MIS Protein Leu25-Arg560 Accession #Q6GTN3
- Formulation:
- Supplied as a 0.2 um filtered solution in PBS with 0.05% Proclin 300, pH 7.3.
- Species:
- Human
- Uniprot:
- P03971
- Synonyms:
- anti-Muellerian hormone;MIF;MIS;muellerian-inhibiting factor;muellerian-inhibiting substance;Mullerian inhibiting factor;Mullerian inhibiting substance
- Extra Details:
- This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome.
- Shipping Conditions:
- Dry Ice