AP1629
Phospho-eNOS-S1177 Rabbit monoclonal antibody
Size
POA
- SKU:
- AP1629
- Additional Names:
- 2310065A03Rik|ecNOS|eNOS|Nos-3
- Application:
- ELISA, WB
- Molecular Weight:
- 140 kDa
- Species Reactivity:
- Mouse
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Immunogen:
- Synthetic peptide. This information is considered to be commercially sensitive.
- Formulation:
- Phospho S1177
- Uniprot:
- P70313
- Synonyms:
- 2310065A03Rik;cNOS;constitutive NOS;e;ec;EC-NOS;ECNOS;endothelial nitric oxide synthase;endothelial NOS;eNOS;nitric oxide synthase 3 (endothelial cell);nitric oxide synthase 3 transcript variant eNOS-delta20;nitric oxide synthase 3 transcript variant eNOS-delta20-21;nitric oxide synthase 3 transcript variant eNOS-delta21;nitric oxide synthase, endothelial;No;NOS type III;Nos-3;NOSIII
- Extra Details:
- Enables nitric-oxide synthase activity and scaffold protein binding activity. Involved in several processes, including heart development; negative regulation of muscle hyperplasia; and smooth muscle hyperplasia. Acts upstream of with a positive effect on positive regulation of gene expression. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; nitric oxide biosynthetic process; and regulation of metal ion transport. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; hemolymphoid system gland; and nervous system. Used to study aortic valve disease; essential hypertension; persistent fetal circulation syndrome; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); eye disease (multiple); leukemia (multiple); reproductive organ cancer (multiple); and vasculitis (multiple). Orthologous to human NOS3 (nitric oxide synthase 3). The two most thoroughly studied sites are the activation site Ser1177 and the inhibitory site Thr495 . Several protein kinases including Akt/PKB, PKA, and AMPK activate eNOS by phosphorylating Ser1177 in response to various stimuli . In contrast, bradykinin and H2O2 activate eNOS activity by promoting both Ser1177 phosphorylation and Thr495 dephosphorylation.
- Shipping Conditions:
- Blue Ice