AP1621
Phospho-LATS1-S909+LATS2-S872 Rabbit monoclonal antibody
Size
POA
- SKU:
- AP1621
- Additional Names:
- KPM|LATS1|LATS2|phospho-LATS1-S909/LATS2-S872|WARTS|wts
- Application:
- ELISA, WB, IHC-P
- Molecular Weight:
- 140 kDa
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Immunogen:
- Synthetic peptide. This information is considered to be commercially sensitive.
- Formulation:
- Phospho S909,Phospho S872
- Uniprot:
- O95835, Q9NRM7
- Synonyms:
- h-warts;kinase phosphorylated during mitosis protein;KPM;large tumor suppressor homolog 1;large tumor suppressor homolog 2;LATS (large tumor suppressor, Drosophila) homolog 1;LATS (large tumor suppressor, Drosophila) homolog 2;LATS, large tumor suppressor, homolog 1;LATS, large tumor suppressor, homolog 2;serine/threonine kinase KPM;serine/threonine-protein kinase kpm;serine/threonine-protein kinase LATS1;serine/threonine-protein kinase LATS2;WARTS;WARTS protein kinase;warts-like kinase;wts
- Extra Details:
- The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
- Shipping Conditions:
- Blue Ice