A8345
CHM Rabbit polyclonal antibody
Size
£151.00
- SKU:
- A8345
- Additional Names:
- CHM|DXS540|GGTA|HSD-32|REP-1|TCD
- Application:
- ELISA, WB
- Molecular Weight:
- 101kDa
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Host:
- Rabbit
- Reactivities:
- Human
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Formulation:
- Unmodified
- Sequence:
- KNHALVTSANSTEAADSAFLPTEDESLSTMSCEMLTEQTPSSDPENALEVNGAEVTGEKENHCDDKTCVPSTSAEDMSENVPIAEDTTEQP
- Uniprot:
- P24386
- Synonyms:
- CHM, Rab escort protein 1;choroideremia (Rab escort protein 1);Choroideremia protein;DXS540;GGTA;HSD-32;Rab escort protein 1;rab proteins geranylgeranyltransferase component A 1;REP-1;TCD;TCD protein
- Extra Details:
- This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene.
- Shipping Conditions:
- Blue Ice