A8293
APITD1 Rabbit polyclonal antibody
Size
£152.00
- SKU:
- A8293
- Additional Names:
- APITD1|CENP-S|FAAP16|MHF1
- Application:
- ELISA, WB
- Molecular Weight:
- 16kDa
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Host:
- Rabbit
- Reactivities:
- Human
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Formulation:
- Unmodified
- Sequence:
- MEEEAETEEQQRFSYQQRLKAAVHYTVGCLCEEVALDKEMQFSKQTIAAISELTFRQCENFAKDLEMFARHAKRTTINTEDVKLLARRSNSLLKYITDKSEEIAQINLERKAQKKKKSEDGSKNSRQPAEAGVVESEN
- Uniprot:
- Q8N2Z9
- Synonyms:
- APITD1;APITD1-CORT;APITD1-CORT protein;APITD1-CORT readthrough;apoptosis-inducing TAF9-like domain-containing protein 1;apoptosis-inducing, TAF9-like domain 1;CENP-S;CENPS;centromere protein S;FAAP16;FANCM associated histone fold protein 1;FANCM-associated histone fold protein 1;FANCM-interacting histone fold protein 1;Fanconi anemia-associated polypeptide of 16 kDa;MHF1
- Extra Details:
- This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7.
- Shipping Conditions:
- Blue Ice