A6876
ATP6V1B1 Rabbit polyclonal antibody
Size
£152.00
- SKU:
- A6876
- Additional Names:
- ATP6B1|ATP6V1B1|DRTA2|RTA1B|VATB|VMA2|VPP3
- Application:
- ELISA, WB, IF
- Molecular Weight:
- 57kda
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Formulation:
- Unmodified
- Sequence:
- MAMEIDSRPGGLPGSSCNLGAAREHMQAVTRNYITHPRVTYRTVCSVNGPLVVLDRVKFAQYAEIVHFTLPDGTQRSGQVLEVAGTKAIVQVFEGTSGIDARKTTCEFTGDILRTPVSEDMLGRVFNGSGKPIDKGPVVMAEDFLDINGQPINPHSRIYPEEMIQTGISPIDVMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKAVLDYHDDNFAIVFAAMGVNMETARFFKSDFEQNGTMGNVCLFLNLANDPTIERIITPRLALTTAEFLA
- Uniprot:
- P15313
- Synonyms:
- ATP6B1;ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1;DRTA2;endomembrane proton pump 58 kDa subunit;H(+)-transporting two-sector ATPase, 58kD subunit;H+-ATPase beta 1 subunit;RTA1B;V-ATPase B1 subunit;V-ATPase subunit B 1;V-type proton ATPase subunit B, kidney isoform;vacuolar proton pump 3;vacuolar proton pump subunit B 1;vacuolar proton pump, subunit 3;VATB;VMA2;VPP3
- Extra Details:
- This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness.
- Shipping Conditions:
- Blue Ice