[KO Validated] XIAP Rabbit polyclonal antibody

Size

POA

SKU:: A6869
Additional Names:: AP|API3|BIRC4|hIAP-3|hIAP3|IAP-3|ILP1|MIHA|XLP2
Application:: ELISA, WB
Molecular Weight:: 54kDa
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Sequence:: VQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS
Uniprot:: P98170
Synonyms:: API3;baculoviral IAP repeat-containing protein 4;BIRC4;E3 ubiquitin-protein ligase XIAP;hIAP-3;hIAP3;IAP-3;IAP-like protein;IAP-like protein 1;ILP1;inhibitor of apoptosis protein 3;MIHA;RING-type E3 ubiquitin transferase XIAP;X-linked IAP;X-linked inhibitor of apoptosis protein;X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase;XLP2
Extra Details:: This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.

Shipping Conditions:: Blue Ice