A6816
PHOX2B Rabbit monoclonal antibody
Size
POA
- SKU:
- A6816
- Additional Names:
- CCHS|NBLST2|NBPhox|PHOX2B|PMX2B
- Application:
- ELISA, WB
- Molecular Weight:
- 35kda
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Immunogen:
- Synthetic peptide. This information is considered to be commercially sensitive.
- Formulation:
- Unmodified
- Sequence:
- GGGPSPAGAPGAAGPGGPGGEPGKGGAAAAAAAAAAAAAAAAAAAAGGLAAAGGPGQGWAPGPGPITSIPDSLGGPFASVLSSLQRPNGAKAALVKSSMF
- Uniprot:
- Q99453
- Synonyms:
- CCHS;NBLST2;NBPhox;neuroblastoma paired-type homeobox protein;neuroblastoma Phox;paired like homeobox2B;paired mesoderm homeobox 2b;paired mesoderm homeobox protein 2B;Paired-like homeobox 2B;PHOX2B homeodomain protein;PMX2B
- Extra Details:
- The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.
- Shipping Conditions:
- Blue Ice