DDX3X Rabbit polyclonal antibody

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£152.00

SKU:: A5637
Additional Names:: CAP-Rf|DBX|DDX14|DDX3|DDX3X|HLP2|MRX102|MRXSSB
Application:: ELISA, WB, IHC-P, IF, ICC, IP
Molecular Weight:: 75kDa
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Immunogen:: Synthetic peptide. This information is considered to be commercially sensitive.
Formulation:: Unmodified
Sequence:: MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRG
Uniprot:: O00571
Synonyms:: ATP-dependent RNA helicase DDX3X;CAP-Rf;DBX;DDX14;DDX3;DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked;DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked;DEAD box protein 3, X-chromosomal;DEAD box, X isoform;DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3;DEAD/H box-3;helicase-like protein 2;HLP2;MRX102;MRXSSB
Extra Details:: The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants.

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