A5579
MLKL Rabbit polyclonal antibody
Size
POA
- SKU:
- A5579
- Additional Names:
- 9130019I15Rik|MLKL
- Application:
- ELISA, WB, IHC-P, IF
- Molecular Weight:
- 54kDa
- Species Reactivity:
- Mouse
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Formulation:
- Unmodified
- Sequence:
- MDKLGQIIKLGQLIYEQCEKMKYCRKQCQRLGNRVHGLLQPLQRLQAQGKKNL
- Uniprot:
- Q9D2Y4
- Synonyms:
- 9130019I15Rik;hMLKL;mixed lineage kinase domain-like protein
- Extra Details:
- This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene.
- Shipping Conditions:
- Blue Ice