SUV39H1 Rabbit polyclonal antibody

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£152.00

SKU:: A3277
Additional Names:: H3-K9-HMTase 1|KMT1A|MG44|SUV39H|SUV39H1
Application:: ELISA, WB, IHC-P
Molecular Weight:: 48kDa
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Sequence:: MAENLKGCSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKKIREQEYYLVKWRGYPDSESTWEPRQNLKCVRILKQFHKDLERELLRRHHRSKTPRHLDPSLANYLVQKAKQRRALRRWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVGCECQDCLWAPTGGCCPGASLHKFAYNDQGQVRLRAGLPIY
Uniprot:: O43463
Synonyms:: H3-K9-HMTase 1;histone H3-K9 methyltransferase 1;histone-lysine N-methyltransferase SUV39H1;histone-lysine N-methyltransferase, H3 lysine-9 specific 1;KMT1A;lysine N-methyltransferase 1A;MG44;position-effect variegation 3-9 homolog;Su(var)3-9 homolog 1;suppressor of variegation 3-9 homolog 1;SUV39H
Extra Details:: This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants.