PE Rabbit anti-Mouse VEGFR3/Flt-4 monoclonal antibody

Size

POA

SKU:: A28963
Additional Names:: Chy|Flt-4|VEGFR-3|VEGFR3
Application:: Flow Cytometry
Species Reactivity:: Mouse
Purification:: Affinity Purified
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Mouse
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Uniprot:: P35917
Synonyms:: AI323512;CHTD7;Chy;chylous ascites;Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4;Flt-;FLT-4;FLT41;fms related tyrosine kinase 4;fms-like tyrosine kinase 4;LMPH1A;LMPHM1;PCL;primary congenital lymphedema;receptor protein tyrosine kinase;tyrosine-protein kinase receptor FLT4;vascular endothelial growth factor receptor 3;VEGF;VEGF receptor-3;VEGFR;VEGFR-3;VEGFR3
Extra Details:: Vascular endothelial growth factor C (VEGF-C) and VEGF-D constitute a subfamily of vascularogenic VEGF growth factors. VEGF-C is combined into a 58 kDa molecule, consisting of a VEGF homologous domain (VHD), with N-terminal and C-terminal propeptides on both sides. The precursor protein undergoes covalent dimerization and progressive proteolysis to generate a ligand with enhanced affinity for VEGF R3/Flt-4. The fully processed VEGF-C contains only 21 kDa VHD and can additionally bind and activate VEGF R2/KDR/Flk-1. The fully processed human VEGF-C has 98% identical amino acid sequence to that of mouse and rat VEGF-C. The interaction of VEGF-C with VEGF R3 is crucial for lymphangiogenesis (5-8). VEGF-C and VEGF R3 are usually co-expressed during lymphangiogenesis, embryonic development, and various pathological conditions. Overexpression of VEGF-C in tumor cells can induce tumor lymphocyte proliferation, leading to increased lymph flow and metastasis to regional lymph nodes. It also induces physiological and tumor-specific angiogenesis and sprouting through interaction with VEGF R2.

Shipping Conditions:: Blue Ice