PE Rabbit anti-Human/Monkey TCR G Gamma/D Delta monoclonal antibody

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POA

SKU:: A28918
Additional Names:: TCRD|TCRDV1|TCRG|TRD@|TRG@
Application:: Flow Cytometry
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Synonyms:: T-cell antigen receptor, delta polypeptide;T-cell antigen receptor, gamma polypeptide;T-cell rearranging gene, gamma;T-cell receptor, delta (V,D,J,C);T-cell receptor, gamma cluster;TCRD;TCRD, TRD@;TCRDV1;TCRG;TCRG, TRG@;TRD@;TRG@
Extra Details:: The G GammaD Delta T-cell receptor (TCR) is a heterodimer composed of G Gamma and D Delta chains, expressed on the T-cell surface and involved in antigen recognition. The engagement of the G GammaD Delta TCR with antigen triggers the phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) within the CD3 chains. Unlike A AlphaB Beta T cells, human G GammaD Delta T cells recognize and kill transformed cells in a manner unrestricted by human leukocyte antigen (HLA) presentation. G GammaD Delta T lymphocytes primarily develop in the thymus, where their defining receptor is generated through RAG-mediated recombination of a relatively limited repertoire of variable (V), diversity (D), and joining (J) gene segments. In addition to the T-cell receptor, G GammaD Delta T cells often express activating natural killer (NK) receptors, which bind to stress-induced surface molecules frequently expressed on malignant cells.

Shipping Conditions:: Blue Ice