Nectin-4 Rabbit monoclonal antibody

Size

POA

SKU:: A28915
Additional Names:: EDSS1|LNIR|nectin-4|PRR4|PVRL4
Application:: ELISA, WB, IHC-P, IF, ICC
Molecular Weight:: 55-80 kDa
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Uniprot:: Q96NY8
Synonyms:: EDSS1;Ig superfamily receptor LNIR;LNIR;nectin 4;Nectin cell adhesion molecule 4;nectin-4;poliovirus receptor-related 4;poliovirus receptor-related protein 4;PRR4;PVRL4
Extra Details:: This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.