A28829
MRP2/ABCC2 Rabbit monoclonal antibody
Size
POA
- SKU:
- A28829
- Additional Names:
- ABC30|CMOAT|cMRP|DJS|MRP2|MRP2/ABCC2
- Application:
- ELISA, WB, IHC-P
- Molecular Weight:
- 170-250 kDa
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Formulation:
- Unmodified
- Uniprot:
- Q92887
- Synonyms:
- ABC30;ATP-binding cassette sub-family C member 2;ATP-binding cassette, sub-family C (CFTR/MRP), member 2;canalicular multidrug resistance protein;canalicular multispecific organic anion transporter 1;CMOAT;cMRP;DJS;MRP2;multidrug resistance-associated protein 2
- Extra Details:
- The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
- Shipping Conditions:
- Blue Ice