ABflo[R] 488 Rabbit anti-Human CA125/MUC16 monoclonal antibody

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POA

SKU:: A28811
Additional Names:: CA125
Application:: Flow Cytometry
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Uniprot:: Q8WXI7
Synonyms:: CA125;CA125 ovarian cancer antigen;cancer antigen 125;mucin-16;ovarian cancer-related tumor marker CA125;ovarian carcinoma antigen CA125
Extra Details:: Mucin is a large family of molecules that add a protective layer to respiratory epithelial cells to shield them from microorganisms and pollutants in the local environment. Among the known members of this family, some are produced in a cell-type and tissue-specific manner, suggesting that each mucin member has different biological functions. Some members aggregate after secretion to form a gel-like substance covering the epithelial layer. CA125, also known as MUC16, is a mucin protein that may be found in the form of a transmembrane or secreted protein, used for monitoring the progress of treatment for epithelial ovarian cancer. The CA125 molecule is almost certainly a glycoprotein with an o bond. Its size and charge are uneven, and the most likely reason is that its side chains are constantly de-sulfoglycosylated during its life cycle in body fluids. Under natural conditions, it is a very large complex (possibly up to 400,000 daltons). MUC16 is a member of the mucin family, which are high-molecular-weight, O-glycosylated proteins that play an important role in the formation of mucosal barriers and are found on the top surface of epithelial cells. It contains an amino-terminal extracellular domain, a large tandem repeat sequence, and a transmembrane domain with a short cytoplasmic domain. MUC16 is associated with lung cancer and ovarian cancer. It provides a protective lubricating barrier against particles and pathogens on the mucosal surface.

Shipping Conditions:: Blue Ice