APC Rabbit anti-Human CD49d monoclonal antibody

Size

POA

SKU:: A28806
Additional Names:: CD49D|IA4
Application:: Flow Cytometry
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Uniprot:: P13612
Synonyms:: 269C wild type;alpha 4 subunit of VLA-4 receptor;antigen CD49D, alpha-4 subunit of VLA-4 receptor;CD49 antigen-like family member D;CD49D;IA4;integrin alpha-4;integrin alpha-IV;very late activation protein 4 receptor, alpha 4 subunit;VLA-4 subunit alpha
Extra Details:: CD49d is a 150 kD A Alpha integrin chain, also known as A Alpha4 integrin or VLA-4A Alpha chain. It forms heterodimers with integrin B Beta1 (A Alpha4B Beta1, VLA-4) or B Beta7 (A Alpha4B Beta7). CD49d is widely expressed on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells and some non-hematopoietic cells, but is not expressed on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. A Alpha4B Beta7 is the receptor for VCAM-1 and MAdCAM-1. CD49d is involved in the transport of monocytes to endothelial inflammatory sites and plays a role in cell-cell interactions and cell adhesion to the extracellular matrix. CD49d is involved in lymphocyte migration, T cell activation and hematopoietic stem cell differentiation. CD49d is a marker for the isolation and purification of pure Treg cell populations because it is absent on Foxp3+ cells.

Shipping Conditions:: Blue Ice