APC Rabbit anti-Human/Monkey CD11b monoclonal antibody

Size

POA

SKU:: A28770
Additional Names:: CD11B|CR3A|HNA-4|MAC-1|MAC1A|MO1A|SLEB6
Application:: Flow Cytometry
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Uniprot:: P11215
Synonyms:: antigen CD11b (p170);CD11 antigen-like family member B;CD11B;cell surface glycoprotein MAC-1 subunit alpha;complement component 3 receptor 3 subunit;CR-3 alpha chain;CR3A;integrin alpha-M;integrin, alpha M (complement component 3 receptor 3 subunit);leukocyte adhesion receptor MO1;MAC-1;MAC1A;macrophage antigen alpha polypeptide;macrophage-1 antigen alpha subunit;MO1A;Neutrophil adherence receptor;neutrophil adherence receptor alpha-M subunit;SLEB6
Extra Details:: The differentiation antigen cluster molecule 11b (CD11b) / integrin A Alpham (ITGAM) is a transmembrane protein that forms a heterodimer composed of A Alpha and B Beta subunits. CD11b is expressed in myeloid cells and is commonly used as a marker for myeloid cells, such as neutrophils, monocytes, macrophages, and microglia. CD11b is phosphorylated at the Ser1126 site (cytoplasmic tail region) in neutrophils. Studies have shown that this phosphorylation activity plays a role in the process of white blood cells transferring from the bloodstream to tissues. Additionally, genome-wide association studies have indicated that CD11b is associated with autoimmune diseases such as systemic lupus erythematosus (SLE).

Shipping Conditions:: Blue Ice