PerCP/Cyanine5.5 Rabbit anti-Human/Monkey CD86 monoclonal antibody

Size

POA

SKU:: A28689
Additional Names:: B7-2|B7.2|B70|BU63|CD28LG2|CD86 v6|FUN-1|LAB72
Application:: Flow Cytometry
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Uniprot:: P42081
Synonyms:: Activation B7-2 antigen;B-lymphocyte activation antigen B7-2;B7-2;B7.2;B70;BU63;CD28LG2;CD86 antigen (CD28 antigen ligand 2, B7-2 antigen);CTLA-4 counter-receptor B7.2;FUN-1;LAB72;T-lymphocyte activation antigen CD86
Extra Details:: CD86 is an 80 kDa member of the immunoglobulin superfamily, also known as B7-2, B70, and Ly-58. It is expressed on activated B cells and T cells, monocytes/macrophages, dendritic cells, and astrocytes. Together with CD80, CD86 serves as a ligand for both CD28 and CD152 (CTLA-4). During immune responses, CD86 is generally expressed earlier than CD80. CD86 has also been shown to participate in immunoglobulin class switching and to trigger NK cell-mediated cytotoxicity. Upon binding to CD28, CD86 transduces co-stimulatory signals that promote T cell activation, proliferation, and cytokine production. Conversely, engagement of CD86 with CD152 (CTLA-4) delivers inhibitory signals to T cells.