APC Mouse anti-Human CD192/CCR2 monoclonal antibody

Size

POA

SKU:: A28626
Additional Names:: CC-CKR-2|CCR-2|CCR2A|CCR2B|CD192|CKR2|CKR2A|CKR2B|CMKBR2|MCP-1-R
Application:: Flow Cytometry
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Mouse
Reactivities:: Human
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Uniprot:: P41597
Synonyms:: C-C chemokine receptor type 2;CC-CKR-2;CCR-2;CCR2A;CCR2B;CD192;chemokine (C-C motif) receptor 2;CKR2;CKR2A;CKR2B;CMKBR2;MCP-1 receptor;MCP-1-R;monocyte chemoattractant protein 1 receptor;monocyte chemotactic protein 1 receptor
Extra Details:: CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, -2, -3, and -4). Two alternatively spliced variants (CCR2A and CCR2B) were initially described, which differ in their C-terminal cytoplasmic tails. The adhesion of monocytes to arterial endothelium and their subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. Both CCR2 and MCP-1 are implicated in atherosclerotic plaque formation. MCP-1, induced in endothelial cells by modified low-density lipoprotein (LDL), may trigger firm monocyte attachment to the vascular endothelium under flow conditions. Local overexpression of MCP-1 within the vessel wall induces macrophage infiltration and the development of atherosclerotic lesions. Obesity induces a state of chronic inflammation, which is associated with numerous clinically significant complications, including insulin resistance, diabetes mellitus, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 plays a critical role in the development of obesity and the associated inflammation within adipose tissue.

Shipping Conditions:: Blue Ice