[KD Validated] TSG101 Rabbit monoclonal antibody

Size

POA

SKU:: A28611
Additional Names:: TSG10|VPS23
Application:: ELISA, WB, IHC-P, IF, ICC
Molecular Weight:: 50 kDa
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Immunogen:: Synthetic peptide. This information is considered to be commercially sensitive.
Formulation:: Unmodified
Uniprot:: Q99816
Synonyms:: ESCRT-I complex subunit TSG101;TSG10;tumor susceptibility gene 10;tumor susceptibility gene 101;tumor susceptibility gene 101 protein;tumor susceptibility protein;VPS23
Extra Details:: The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.