PE Rabbit anti-Monkey CD22 monoclonal antibody

Size

POA

SKU:: A28610
Additional Names:: SIGLEC-2|SIGLEC2
Application:: Flow Cytometry
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Synonyms:: B-cell receptor CD22;B-lymphocyte cell adhesion molecule;BL-CAM;CD22 antigen;sialic acid-binding Ig-like lectin 2;SIGLEC-2;SIGLEC2;T-cell surface antigen Leu-14
Extra Details:: CD22 is a 130 kDa type I transmembrane glycoprotein, also known as Siglec-2 and BL-CAM. It is a member of the immunoglobulin superfamily (sialoadhesin subgroup). CD22 is expressed in the cytoplasm of pro-B and pre-B cells, and on the surface of mature and activated B cells, but is absent on plasma cells. It is part of the B-cell receptor (BCR) complex and associates with signaling molecules such as SHP-1, Syk, Lck, Lyn, and phospholipase CG Gamma1. The primary function of CD22 is believed to be the limitation of antigen receptor signaling by modulating the threshold for B-cell activation. Studies have shown that CD22 can bind to CD45RO and CD75, although the identity of its natural ligand(s) remains a subject of debate.