ABflo[R] 488 Rat anti Mouse CD172a/SIRPA Alpha monoclonal antibody

Size

POA

SKU:: A28607
Additional Names:: Bit, P84, SIRP, SHP-1, CD172a, Ptpns1, SHPS-1, Idd13.2
Application:: Flow Cytometry
Species Reactivity:: Mouse
Purification:: Affinity Purified
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rat
Reactivities:: Mouse
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Uniprot:: P97797
Synonyms:: AI835480;Bi;Bit;brain Ig-like molecule with tyrosine-based activation motifs;brain immunological-like with tyrosine-based motifs;brain-immunoglobulin-like molecule with tyrosine-based activation motifs;CD172;CD172 antigen-like family member A;CD172a;Idd13.2;inhibitory receptor SHPS-1;macrophage fusion receptor;MFR;mSIRP-alpha1;MYD-1;myD-1 antigen;P8;P84;protein tyrosine phosphatase, non-receptor type substrate 1;Pt;Ptpns1;SHP;SHP substrate 1;SHP-1;SHPS-1;SHPS1;signal-regulatory protein alpha-1;SIRP;sirp-alpha-1;tyrosine phosphatase SHP substrate 1;tyrosine-protein phosphatase non-receptor type substrate 1
Extra Details:: CD172a, also known as SIRPA Alpha, is a type I transmembrane protein featuring an extracellular region with one V-set Ig-like domain and two C-set Ig-like domains, and a cytoplasmic tail containing two immunoreceptor tyrosine-based inhibition motifs (ITIMs) and a proline-rich region. It is expressed by monocytes, macrophages, myeloid cells, and neuronal tissues. Phosphorylation of the SIRPA Alpha ITIMs induces the recruitment and activation of the tyrosine phosphatases PTPN6 (SHP-1) and PTPN11 (SHP-2), leading to the negative regulation of various biological processes. The known ligands for CD172a include CD47, surfactant protein A (SP-A), and surfactant protein D (SP-D).

Shipping Conditions:: Blue Ice