PE Rabbit anti-Mouse PD-1/CD279 monoclonal antibody

Size

POA

SKU:: A28593
Additional Names:: Ly101|PD-1|Pdc1
Application:: Flow Cytometry
Species Reactivity:: Mouse
Purification:: Affinity Purified
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Mouse
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Uniprot:: Q02242
Synonyms:: CD279;hPD-1;hPD-l;hSLE1;Ly101;mPD-1;PD-;PD-1;PD1;Pdc;Pdc1;programmed cell death 1 protein;programmed cell death protein 1;protein PD-1;SLEB2;systemic lupus erythematosus susceptibility 2
Extra Details:: CD279, also known as programmed death 1 (PD-1), is expressed on activated splenic T cells, B cells, and thymocytes. Its expression can also be induced on activated myeloid cells. PD-1 participates in lymphocyte clonal selection and peripheral tolerance by binding to its ligands B7-H1 (PD-L1) and B7-DC (PD-L2). The interaction between PD-1 and PD-L1 has been reported to be crucial for positive selection and plays a role in shaping the T-cell repertoire. Negative co-stimulation via PD-L1 is essential for the long-term survival of intratesticular islet allografts.