APC Rabbit anti-Human CD114/G-CSFR monoclonal antibody

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POA

SKU:: A28578
Additional Names:: CD114|GCSFR|SCN7
Application:: Flow Cytometry
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Uniprot:: Q99062
Synonyms:: CD114;CD114 antigen;colony stimulating factor 3 receptor (granulocyte);G-CSF receptor;G-CSF-R;GCSFR;granulocyte colony-stimulating factor receptor;SCN7
Extra Details:: The granulocyte colony-stimulating factor receptor (G-CSF-R) is a transmembrane protein composed of an immunoglobulin-like (Ig-like) domain, a cytokine receptor homology (CRH) domain, and three fibronectin type III (FN III) domains. G-CSF-R is expressed across all granulocyte lineages, including progenitor cells, and has also been detected in monocytes, T and B lymphocytes, and non-hematopoietic tissues such as cardiomyocytes and neural stem cells. Its primary ligand is the cytokine granulocyte colony-stimulating factor (G-CSF). Lacking intrinsic tyrosine kinase activity, G-CSF-R undergoes a conformational change upon ligand binding, leading to the activation of downstream signaling pathways including Jak/Stat, PI3K/Akt, and MAPK. G-CSF promotes the differentiation and proliferation of myeloid progenitors into neutrophils. Mutations in the G-CSF-R gene, CSF3R, are associated with multiple disorders, including severe congenital neutropenia (SCN), chronic neutrophilic leukemia (CNL), and atypical chronic myeloid leukemia (aCML).

Shipping Conditions:: Blue Ice