ABflo[R] 450 Rat anti-Mouse CD16/CD32 monoclonal antibody

Size

POA

SKU:: A28535
Additional Names:: CD16|CD32|F630109E10Rik|Fc[g]RII|Fcgr2|Fcgr2a|FcgRII|Fcr-2|Fcr-3|fcRII|Ly-17|Ly-m20|LyM-1
Application:: Flow Cytometry
Species Reactivity:: Mouse
Purification:: Affinity Purified
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rat
Reactivities:: Mouse
Immunogen:: Synthetic peptide. This information is considered to be commercially sensitive.
Formulation:: Unmodified
Uniprot:: P08101, P08508
Synonyms:: AI528646;CD16;CD32;F630109E10Rik;fc gamma receptor IIB;Fc gamma receptor III;Fc gamma RIIB;fc-gamma RII;fc-gamma RIII;Fc-gamma-RII;fc-gamma-RIIB;Fc[g];Fc[g]RII;Fcg;Fcg receptor III;Fcgam;Fcgamm;FcgammaRIIB;FcgammaRIII;Fcgr;Fcgr2;Fcgr2a;FcgRII;Fcr-;Fcr-2;Fcr-3;fcRII;fcRIII;igG Fc receptor II beta;igG Fc receptor III;low affinity immunoglobulin gamma Fc region receptor II;low affinity immunoglobulin gamma Fc region receptor II-b;low affinity immunoglobulin gamma Fc region receptor III;Ly-1;Ly-17;Ly-m2;Ly-m20;LyM-;LyM-1;lymphocyte antigen 17
Extra Details:: CD16 is a 50-65 kDa cell surface molecule that exists in two isoforms: a transmembrane form expressed by natural killer (NK) cells, and a glycosylphosphatidylinositol (GPI)-anchored form expressed by granulocytes. It serves as a low-affinity receptor for IgG (FcG GammaRIII) and is a critical mediator of antibody-dependent cellular cytotoxicity (ADCC) by NK cells. CD32 (Fcgr2) is a 40 kD transmembrane glycoprotein, member of the immunoglobulin superfamily. The extracellular region of CD32 consists of two Ig C-type domains that binds the Fc region from monomeric IgG with low affinity, but binds immune complexes efficiently. CD32 can mediate phagocytosis of immune complexes and modulate cell activation. CD32 is expressed by Macrophages, neutrophils, mast cells and B cells.

Shipping Conditions:: Blue Ice