APC Rabbit anti-NHP CD45 monoclonal antibody

Size

POA

SKU:: A28472
Additional Names:: L-CA|LCA|Leukocyte Common Ag|Pan Leukocyte, NHP-specific|PTPRC
Application:: Flow Cytometry
Species Reactivity:: Non-human Primate
Purification:: Affinity Purified
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Species:: Non-human Primate
Synonyms:: B220;CD45;CD45 antigen;CD45R;GP180;L-CA;LCA;LY5;protein tyrosine phosphatase, receptor type, c polypeptide;receptor-type tyrosine-protein phosphatase C;T200;T200 glycoprotein;T200 leukocyte common antigen
Extra Details:: CD45 is a receptor-type protein tyrosine phosphatase, also known as Ly-5 or the leukocyte common antigen. It functions primarily by regulating the activation of Src family protein tyrosine kinases, such as Lck and Fyn, thereby initiating T cell receptor signaling. Deficiency in CD45 results in dysfunctional T and B lymphocytes, leading to severe combined immunodeficiency. Furthermore, CD45 plays a significant role in the pathogenesis of autoimmune diseases, cancer, and infectious diseases, including fungal infections.