A28406
IRS1 Rabbit polyclonal antibody
Size
£152.00
- SKU:
- A28406
- Additional Names:
- G972R|IRS-1
- Application:
- ELISA, WB
- Molecular Weight:
- 180 kDa
- Species Reactivity:
- Mouse
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Host:
- Rabbit
- Reactivities:
- Mouse
- Immunogen:
- Synthetic peptide. This information is considered to be commercially sensitive.
- Formulation:
- Unmodified
- Uniprot:
- P35569
- Synonyms:
- G972;G972R;HIRS-1;insulin receptor substrate 1;IR;IRS-1
- Extra Details:
- Enables phosphatidylinositol 3-kinase activator activity; phosphatidylinositol 3-kinase binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in cellular response to fatty acid; insulin receptor signaling pathway; and insulin-like growth factor receptor signaling pathway. Acts upstream of or within several processes, including cellular response to insulin stimulus; positive regulation of epithelial cell migration; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in several cellular components, including ciliary basal body; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; type 2 diabetes mellitus; and uterine fibroid. Orthologous to human IRS1 (insulin receptor substrate 1).
- Shipping Conditions:
- Blue Ice