Nephrin Rabbit monoclonal antibody

Size

POA

SKU:: A28348
Additional Names:: nephrin|NephrinB
Application:: ELISA, WB, IHC-P, IF
Molecular Weight:: 135-200 kDa
Species Reactivity:: Mouse
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Mouse
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Sequence:: LGDSGLTDKGIQVSITTPGLDQAPEDTDQPLPTEQPPGPPRLPLLPVLFAVGGLLLLSNASCVGGLLWRRRLRRLAEEISEKTEAGSEEDRIRNEYEESQWTGDRDTRSSTVSTAEVDPHYYSMRDFSPQLPPTLEEVSYRQAFTGIEDEDMAFPGHLYDEVERVYGPPGVWGPLYDEVQMDPYDLRWPEVKYEDPRGIYDQVAADMDAGEPGSLPFELRGHLV
Uniprot:: Q9QZS7
Synonyms:: CNF;ne;nephrin;nephrin 1;NephrinB;nephrosis 1 homolog, nephrin;nephrosis 1, congenital, Finnish type (nephrin);NPHN;NPHS1, nephrin;renal glomerulus-specific cell adhesion receptor;truncated NPHS1
Extra Details:: Predicted to enable cell adhesion molecule binding activity; cytoskeletal protein binding activity; and protein domain specific binding activity. Involved in myoblast fusion; skeletal muscle tissue development; and slit diaphragm assembly. Acts upstream of or within several processes, including JNK cascade; cell adhesion; and positive regulation of actin filament polymerization. Located in cell projection; focal adhesion; and plasma membrane. Is active in cell periphery. Is expressed in central nervous system; metanephros; and skeletal muscle. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 1. Orthologous to human NPHS1 (NPHS1 adhesion molecule, nephrin).

Shipping Conditions:: Blue Ice