ABflo[R] 488 Rabbit anti-Human CD206/MMR monoclonal antibody

Size

POA

SKU:: A28285
Additional Names:: bA541I19.1|CD206|CLEC13D|CLEC13DL|hMR|MMR|MRC1L1
Application:: Flow Cytometry
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Sequence:: LLDTRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRWVSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYGNRQEKNIMLYKGSGLWSRWKIYGTTDNLCSRGYEAMYTLLGNANGATCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPLTSVSYQINSKSALTWHQARKSCQQQNAELLSITEIHEQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRYLNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNTTLNSFVIPSESDVPTHCPSQWWPYAGHCYKIHRDEKKIQRDALTTCRKEGGDLTSIHTIEELDFIISQLGYEPNDELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKGKDGYWADRGCEWPLGYICKMKSRSQGPEIVEVEKGCRKGWKKHHFYCYMIGHTLSTFAEANQTCNNENAYLTTIEDRYEQAFLTSFVGLRPEKYFWTGLSDIQTKGTFQWTIEEEVRFTHWNSDMPGRKPGCVAMRTGIAGGLWDVLKCDEKAKFVCKHWAEGVTHPPKPTTTPEPKCPEDWGASSRTSLCFKLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYGSPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQKGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQSESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCVTMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIFGFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTFLWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEAGKWMDDTCDSKRGYICQTRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNAFAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWKTAHCNESFYFLCKRSDEIPATEPPQLPGRCPESDHTAWIPFHGHCYYIESSYTRNWGQASLECLRMGSSLVSIESAAESSFLSYRVEPLKSKTNFWIGLFRNVEGTWLWINNSPVSFVNWNTGDPSGERNDCVALHASSGFWSNIHCSSYKGYICKRPKIIDAKPTHELLTTKADTRKMDPSKPSSNVA
Uniprot:: P22897
Synonyms:: bA541I19.1;C-type lectin domain family 13 member D;C-type lectin domain family 13 member D-like;CD206;CLEC13D;CLEC13DL;hMR;human mannose receptor;macrophage mannose receptor 1;macrophage mannose receptor 1-like protein 1;mannose receptor, C type 1-like 1;MMR;MRC1L1
Extra Details:: The mannose receptor (MR/CLEC13D/CD206/MMR/MRC1/Macrophage Mannose Receptor 1) is an endocytic receptor expressed on dendritic cells, macrophages, and avascular endothelium. It is a highly glycosylated type I transmembrane protein featuring three distinct types of extracellular domains and a short carboxyl-terminal cytoplasmic tail that lacks obvious signaling motifs. The extracellular portion of the protein comprises an N-terminal cysteine-rich (CR) domain that binds sulfated sugar chains, a single fibronectin type II (FNII) domain that binds collagen, and eight C-type lectin domains (CTLDs) that recognize carbohydrate ligands containing mannose, fucose, and N-acetylglucosamine (GlcNAc). The receptor continuously cycles between the plasma membrane and early endosomes. Its functions include mediating antigen cross-presentation, facilitating the clearance of endogenous glycoproteins (e.g., maintaining glycoprotein homeostasis), and detecting and transporting pathogens via the lymphatics. The mannose receptor is a canonical marker for M2 macrophages.

Shipping Conditions:: Blue Ice