A27707
P Glycoprotein Rabbit monoclonal antibody
Size
POA
- SKU:
- A27707
- Additional Names:
- ABC20|CD243|CLCS|GP170|MDR1|p-170|P-GP|PGY1
- Application:
- ELISA, WB, IHC-P, IF
- Molecular Weight:
- 140-160kDa
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Formulation:
- Unmodified
- Sequence:
- DGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESI
- Uniprot:
- P08183
- Synonyms:
- ABC20;ATP-binding cassette sub-family B member 1;ATP-binding cassette, sub-family B (MDR/TAP), member 1;ATP-dependent translocase ABCB1;CD243;CLCS;colchicin sensitivity;doxorubicin resistance;GP170;MDR1;multidrug resistance protein 1;p-170;P-glycoprotein 1;P-GP;PGY1;phospholipid transporter ABCB1
- Extra Details:
- The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
- Shipping Conditions:
- Blue Ice