A25100
Chicken IL12B Rabbit polyclonal antibody
Size
POA
- SKU:
- A25100
- Additional Names:
- IL-12B|IL-12p40
- Application:
- ELISA, WB
- Molecular Weight:
- 45kDa
- Species Reactivity:
- Avian
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Host:
- Rabbit
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Formulation:
- Unmodified
- Species:
- Avian
- Sequence:
- QWKLRENVYVIESEWNDETPAKKVKLTCDTSDEALPVYWKKGTELKGTGKTLTTEVKEFPDAGNYTCLSAKTHEIISYSFFLITKVDSNGQMIRSILKSYKEPSKTFLKCEAKNYSGIFTCSWMTENESPSVKFTIRSLKGSQGDVTCSSPVARTDKSVTEYTAQCQKENYCPFAEEHQPTEMFLEVIDEVEYENYTSSFFIRDIIKPDPPQCQYASTNGTVTWTYPKTWSTPKSYFPLTFRVKVESTKKYKSKVYDADEQSIQIPKTGPKDKISVQARDRYYNSSWSEWSTLCR
- Uniprot:
- Q6X0K9
- Synonyms:
- Cytotoxic lymphocyte maturation factor 40 kDa subunit;IL-12 p40 subunit;IL-12 subunit p40;IL-12B;IL-12p40;interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40);interleukin-12 beta chain;interleukin-12 p40 subunit;interleukin-12 subunit beta;interleukin-12p40
- Extra Details:
- Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
- Shipping Conditions:
- Blue Ice