A24864
Irf3 Rabbit polyclonal antibody
Size
£152.00
- SKU:
- A24864
- Additional Names:
- IRF-3,IIAE7,IRF 3
- Application:
- ELISA, WB, IHC-P
- Molecular Weight:
- 47kda
- Species Reactivity:
- Mouse
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Formulation:
- Unmodified
- Uniprot:
- P70671
- Synonyms:
- C920001K05Rik;IIAE7;interferon regulatory factor 3;IRF;IRF-3
- Extra Details:
- Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains.
- Shipping Conditions:
- Blue Ice