A24046
ALPK1 Rabbit monoclonal antibody
Size
POA
- SKU:
- A24046
- Additional Names:
- Alpha-kinase 1|ALPK1
- Application:
- ELISA, WB, IHC-P
- Molecular Weight:
- 139kDa
- Species Reactivity:
- Mouse
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Host:
- Rabbit
- Reactivities:
- Mouse, Rat
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Formulation:
- Unmodified
- Sequence:
- PDKKGISTSLGILADIFVSMSKTDYEKFKKSPKVNLALLKEFDHHLLSASEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSCSADCPPGMKSVHLCEAKEAFEIGLLTKKDGELVSGKQELHSFIKAAFGLTTVHSRLHGETDAVRAARQLCSEAVGKLYTFSTSPTSQDREGLSQEIMSLISQVKGHLRVQSFPNLDACSYVPESFKCGLDRLILHGHVDFQQILETYSQHHTSVCEVFESTCGNSK
- Uniprot:
- E9QNX4
- Synonyms:
- 8430410J10Rik;alpha-protein kinase 1;chromosome 4 kinase;LAK;lymphocyte alpha-kinase;lymphocyte alpha-protein kinase;ROSAH
- Extra Details:
- A Alpha- Protein Kinase 1, also known as A Alpha- ALPK1 is associated with chronic kidney disease (CKD), myocardial infarction, gout and type 2 diabetes. According to reports, ALPK1 mutations can lead to serious deficits in motor coordination in mice. ALPK1 can enhance the expression of pro-inflammatory cytokines, including IL-1, in cultured human THP1 and human embryonic kidney 293 (HEK293) cells (PMID: 31557402, PMID: 26275947) B Beta, IL-8 and TGF- B Beta 1. The ALPK1 short subtype (108 kDa) is highly expressed in the brain, spinal cord, heart, lungs, spleen, thymus, small intestine, skin, and testes, while detecting skeletal muscle and kidney. ALPK1 isoform (130 kDa) appears in the heart, lungs, thymus, and skin. As a novel innate immune receptor, ALPK1 can recognize bacteria-derived small molecule ADP-heptose and activate the immune response (PubMed: 30111836, PubMed: 30111836)
- Shipping Conditions:
- Blue Ice