A2177
LCK Rabbit polyclonal antibody
Size
£152.00
- SKU:
- A2177
- Additional Names:
- IMD22|LCK|LSK|p56lck|pp58lck|YT16
- Application:
- ELISA, WB, IHC-P
- Molecular Weight:
- 58kDa
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Formulation:
- Unmodified
- Sequence:
- MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
- Uniprot:
- P06239
- Synonyms:
- IMD22;leukocyte C-terminal Src kinase;LSK;lymphocyte cell-specific protein-tyrosine kinase;p56-LCK;p56(LSTRA) protein-tyrosine kinase;p56lck;pp58lck;Protein YT16;Proto-oncogene Lck;proto-oncogene tyrosine-protein kinase LCK;t cell-specific protein-tyrosine kinase;T-lymphocyte specific protein tyrosine kinase p56lck;tyrosine-protein kinase Lck;YT16
- Extra Details:
- This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described.
- Shipping Conditions:
- Blue Ice