Caspase-1 Rat monoclonal antibody

Size

POA

SKU:: A21085
Additional Names:: ICE|Il1bc
Application:: ELISA, WB
Molecular Weight:: 48 kDa
Species Reactivity:: Mouse
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rat
Reactivities:: Mouse
Immunogen:: Recombinant fusion protein containing a sequence corresponding to amino acids 206-220aa of mouse Caspase-1.
Formulation:: Unmodified
Sequence:: TALEMVKEVKEFAAC
Uniprot:: P29452
Synonyms:: Casp;CASP-1;CASP1 nirs variant 1;caspase 1, apoptosis-related cysteine peptidase;caspase-1;caspase-1 isoform alpha;IC;ICE;IL-1 beta-converting enzyme;IL-1B converting enzyme;IL-1BC;Il1;IL1B-convertase;IL1BC;interleukin 1-B converting enzyme;interleukin 1, beta, convertase;interleukin-1 beta convertase;interleukin-1 beta-converting enzyme;P45
Extra Details:: Enables cysteine-type endopeptidase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-1 beta production; and protein autoprocessing. Acts upstream of or within several processes, including membrane hyperpolarization; mitochondrial depolarization; and positive regulation of interleukin-1 alpha production. Located in extracellular region. Part of IPAF inflammasome complex. Is expressed in knee joint and metanephros. Orthologous to human CASP1 (caspase 1).