SPINK5 / LEKTI Rabbit monoclonal antibody

Size

POA

SKU:: A20916
Additional Names:: LEKTI|LETKI|NETS|NS|SPINK5 / LEKTI|VAKTI
Application:: ELISA, WB
Molecular Weight:: 37kDa/65kDa/145kDa
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Immunogen:: Synthetic peptide. This information is considered to be commercially sensitive.
Formulation:: Unmodified
Sequence:: FKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTRENDPVLGPDGKTHGNKCAMCAEL
Uniprot:: Q9NQ38
Synonyms:: LEKTI;LETKI;lympho-epithelial Kazal-type-related inhibitor;lymphoepithelial Kazal-type-related inhibitor;NETS;NS;serine protease inhibitor Kazal-type 5;VAKTI
Extra Details:: This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants.