JMJD1C Rabbit polyclonal antibody

Size

£152.00

SKU:: A20153
Additional Names:: JMJD1C|KDM3C|TRIP-8|TRIP8
Application:: ELISA, WB, IHC-P
Molecular Weight:: 285kDa
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C 50% glycerol. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Sequence:: KPEEDEKKLNMKRLRTDNVSDFSESSDSENSNKRIIDNSSEQKPENELKNKNTSKINGEEGKPHNNEKAGEETLKNSQPPWDQIQEDKKHEEAEK
Uniprot:: Q15652
Synonyms:: Jumonji domain-containing protein 1C;KDM3C;probable JmjC domain-containing histone demethylation protein 2C;thyroid hormone receptor interactor 8;thyroid receptor-interacting protein 8;TR-interacting protein 8;TRIP-8;TRIP8
Extra Details:: The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants.