USP18 Rabbit polyclonal antibody

Size

£152.00

SKU:: A16739
Additional Names:: ISG43|PTORCH2|UBP43|USP18
Application:: ELISA, WB, IHC-P, IF, ICC
Molecular Weight:: 34kda
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Immunogen:: Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:: MSKAFGLLRQICQSILAESSQSPADLEEKKEEDSNMKREQPRERPRAWDYPHGLVGLHNIGQTCCLNSLIQVFVMNVDFTRILKRITVPRGADEQRRSVP
Uniprot:: Q9UMW8
Synonyms:: 43 kDa ISG15-specific protease;ISG15-specific-processing protease;ISG43;PTORCH2;ubiquitin specific protease 18;ubl carboxyl-terminal hydrolase 18;ubl thioesterase 18;ubl thiolesterase 18;UBP43
Extra Details:: The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15.