SERPINC1 Rabbit polyclonal antibody

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£152.00

SKU:: A1574
Additional Names:: AT3|AT3D|ATIII|ATIII-R2|ATIII-T1|ATIII-T2|SERPINC1|THPH7
Application:: ELISA, WB
Molecular Weight:: 58kDa
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Sequence:: HGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKS
Uniprot:: P01008
Synonyms:: antithrombin-III;AT3;AT3D;ATIII;ATIII-R2;ATIII-T1;ATIII-T2;serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1;Serpin C1;serpin peptidase inhibitor clade C member 1;serpin peptidase inhibitor, clade C (antithrombin), member 1;THPH7
Extra Details:: The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19).

Shipping Conditions:: Blue Ice