Twist Rabbit polyclonal antibody

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£152.00

SKU:: A15596
Additional Names:: ACS3|bHLHa38|BPES2|BPES3|CRS|CRS1|CSO|SCS|SWCOS|TWIST
Application:: ELISA, WB, IHC-P
Molecular Weight:: 25kDa
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Immunogen:: Synthetic peptide. This information is considered to be commercially sensitive.
Formulation:: Unmodified
Sequence:: GPGGAAGGGVGGGDEPGSPAQGKRGKKSAGCGGGGGAGGGGGSSSGGGSPQSYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLK
Uniprot:: Q15672
Synonyms:: ACS3;B-HLH DNA binding protein;bHLHa38;BPES2;BPES3;class A basic helix-loop-helix protein 38;CRS;CRS1;CSO;H-twist;SCS;SWCOS;TWIST;twist basic helix-loop-helix transcription factor 1;twist homolog 1;TWIST homolog of drosophila;twist-related protein 1
Extra Details:: This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis, as well as metastatic recurrence. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism.

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