A14996
LDL Receptor (LDLR) Rabbit polyclonal antibody
Size
£152.00
- SKU:
- A14996
- Additional Names:
- FH|FHC|FHCL1|LDL Receptor (LDLR)|LDLCQ2
- Application:
- ELISA, WB, IHC-P, IF, ICC
- Molecular Weight:
- 100-160kDa
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Immunogen:
- Synthetic peptide. This information is considered to be commercially sensitive.
- Formulation:
- Unmodified
- Sequence:
- TVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLEDDVA
- Uniprot:
- P01130
- Synonyms:
- FH;FHC;FHCL1;LDL receptor;LDLCQ2;low-density lipoprotein receptor;low-density lipoprotein receptor class A domain-containing protein 3
- Extra Details:
- The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
- Shipping Conditions:
- Blue Ice