A14774
PTPRN2 Rabbit polyclonal antibody
Size
£152.00
- SKU:
- A14774
- Additional Names:
- IA-2beta|IAR|ICAAR|PTPRN2|PTPRP|R-PTP-N2
- Application:
- ELISA, WB, IHC-P
- Molecular Weight:
- 111kDa
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Formulation:
- Unmodified
- Sequence:
- AAPSSVPRGRQLPGRLGCLLEEGLCGASEACVNDGVFGRCQKVPAMDFYRYEVSPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRPEASSPARPSKHSVGSERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRPPAEGDDRFSESILTYVAHTSALTYPPGSRTQLREDLLPRTLGQLQPDELSPKVDSGVDRHHL
- Uniprot:
- Q92932
- Synonyms:
- IA-2beta;IAR;IAR/receptor-like protein-tyrosine phosphatase;ICAAR;islet cell autoantigen-related protein;phogrin;protein tyrosine phosphatase receptor pi;protein tyrosine phosphatase, receptor type, N polypeptide 2;PTPRP;R-PTP-N2;receptor-type tyrosine-protein phosphatase N2;tyrosine phosphatase IA-2 beta
- Extra Details:
- This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants.
- Shipping Conditions:
- Blue Ice