Vinculin Rabbit polyclonal antibody

Size

£152.00

SKU:: A14193
Additional Names:: CMD1W|CMH15|HEL114|MV|MVCL|Vinculin
Application:: ELISA, WB, IF, ICC
Molecular Weight:: 124kDa
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Sequence:: AGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPDFPPPPPDLE
Uniprot:: P18206
Synonyms:: CMD1W;CMH15;epididymis luminal protein 114;epididymis secretory sperm binding protein;HEL114;meta-vinculin;metavinculin;MV;MVCL;vinculin;vinculin isoform meta-VCL
Extra Details:: Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.