SSRP1 Rabbit polyclonal antibody

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£152.00

SKU:: A13636
Additional Names:: FACT|FACT80|SSRP1|T160
Application:: ELISA, WB, IHC-P, IF, ICC
Molecular Weight:: 81kda
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Sequence:: MAETLEFNDVYQEVKGSMNDGRLRLSRQGIIFKNSKTGKVDNIQAGELTEGIWRRVALGHGLKLLTKNGHVYKYDGFRESEFEKLSDFFKTHYRLELMEKDLCVKGWNWGTVKFGGQLLSFDIGDQPVFEIPLSNVSQCTTGKNEVTLEFHQNDDAEVSLMEVRFYVPPTQEDGVDPVEAFAQNVLSKADVIQATGDAICIFRELQCLTPRGRYDIRIYPTFLHLHGKTFDYKIPYTTVLRLFLLPHKDQRQMFFVISLDPPIKQGQTRYHFLILLFSKDEDISLTLNMNEEEVEKRFEG
Uniprot:: Q08945
Synonyms:: chromatin-specific transcription elongation factor 80 kDa subunit;cisplatin-DNA SSRP;facilitates chromatin remodeling 80 kDa subunit;facilitates chromatin transcription complex 80 kDa subunit;facilitates chromatin transcription complex subunit SSRP1;FACT;FACT 80 kDa subunit;FACT complex subunit SSRP1;FACT80;FACTp80;high mobility group box;hSSRP1;recombination signal sequence recognition protein 1;Structure-specific recognition protein 1;T160
Extra Details:: The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.

Shipping Conditions:: Blue Ice