UGT1A1 Rabbit polyclonal antibody

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£152.00

SKU:: A1359
Additional Names:: BILIQTL1|GNT1|HUG-BR1|UDPGT|UDPGT 1-1|UGT1|UGT1A|UGT1A1
Application:: ELISA, WB, IHC-P, IF, ICC
Molecular Weight:: 60 kda
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Sequence:: MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVPRPLSSH
Uniprot:: P22309
Synonyms:: BILIQTL1;bilirubin UDP-glucuronosyltranserase;bilirubin UDP-glucuronosyltransferase 1-1;bilirubin UDP-glucuronosyltransferase isozyme 1;bilirubin-specific UDPGT isozyme 1;GNT1;HUG-BR1;UDP glucuronosyltransferase 1 family, polypeptide A1;UDP glycosyltransferase 1 family, polypeptide A1;UDP-glucuronosyltransferase 1-A;UDP-glucuronosyltransferase 1A;UDP-glucuronosyltransferase 1A1;UDPGT;UDPGT 1-1;UGT-1A;UGT1;UGT1-01;UGT1.1;UGT1*1;UGT1A
Extra Details:: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

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