EP300 Rabbit polyclonal antibody

Size

£152.00

SKU:: A13016
Additional Names:: EP300|KAT3B|MKHK2|p300|RSTS2
Application:: ELISA, IHC-P, IF, ICC
Molecular Weight:: Refer to figures
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Uniprot:: Q09472
Synonyms:: E1A-associated protein p300;E1A-binding protein, 300kD;histone acetyltransferase p300;histone butyryltransferase p300;histone crotonyltransferase p300;KAT3B;MKHK2;p300;p300 HAT;protein 2-hydroxyisobutyryltransferase p300;protein lactyltransferas p300;protein propionyltransferase p300;RSTS2
Extra Details:: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.