OTUB1 Rabbit polyclonal antibody

Size

£152.00

SKU:: A11656
Additional Names:: HSPC263|OTB1|OTU1|OTUB1
Application:: ELISA, WB, IF, ICC
Molecular Weight:: 37kDa
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C 50% glycerol. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Sequence:: MAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKDLHKKYSYIRKTRPDGNCFYRAFGFSHLEALLDDSKELQRFKAVSAKSKEDLVSQGFTEFTIEDFHNTFMDLIEQVEKQTSVADLLASFNDQSTSDYLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKESDHIHI
Uniprot:: Q96FW1
Synonyms:: deubiquitinating enzyme OTUB1;HSPC263;OTB1;OTU domain-containing ubiquitin aldehyde-binding protein 1;OTU domain, ubiquitin aldehyde binding 1;OTU-domain Ubal-binding 1;OTU1;otubain-1;ubiquitin thioesterase OTUB1;ubiquitin-specific protease otubain 1;ubiquitin-specific-processing protease OTUB1
Extra Details:: The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.

Shipping Conditions:: Blue Ice