DCPS Rabbit polyclonal antibody

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£152.00

SKU:: A10299
Additional Names:: ARS|DCPS|DCS1|HINT-5|HINT5|HSL1|HSPC015
Application:: ELISA, WB
Molecular Weight:: 38kda
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Abclonal
Host:: Rabbit
Reactivities:: Human, Mouse
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulation:: Unmodified
Sequence:: MADAAPQLGKRKRELDVEEAHAASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDKIIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQGQEAILQRYRMKGDHLRVYLHYL
Uniprot:: Q96C86
Synonyms:: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase;ARS;DCS-1;DCS1;decapping scavenger enzyme;epididymis secretory sperm binding protein;heat shock-like protein 1;HINT-5;hint-related 7meGMP-directed hydrolase;HINT5;histidine triad nucleotide-binding protein 5;histidine triad protein member 5;homolog of C. elegans 7meGMP-directed hydrolase dcs-1;HSL1;HSPC015;m7GpppX diphosphatase;mRNA decapping enzyme;scavenger mRNA-decapping enzyme DcpS
Extra Details:: This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover.

Shipping Conditions:: Blue Ice